MOTS-c
Mitochondrial ORF of the 12S rRNA Type-c (16-mer)
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA. Investigated in metabolic and biogerontology models for its ability to translocate to the nucleus under metabolic stress, activate AMPK (5′ AMP-activated protein kinase), and regulate nuclear gene expression related to glucose utilization and cellular senescence.
Indexed for laboratory in vitro receptor binding assays and cellular synthesis research. Commercial materials are procured as non-clinical reagents under verified laboratory standards.
Chemical Structure & Metrics
Structured Chemical & Preclinical Profile
1. Chemical Identity & Sequence Architecture
MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c (16-mer)) is an analytically characterized peptide with empirical formula C101H152N28O22S2 (MW 2174.6 g/mol). CAS Registry: 1627580-64-6.
2. Primary Preclinical Signaling Axis
Investigated in preclinical assays for cellular signaling: Direct phosphorylation and activation of AMPK signaling cascades in skeletal muscle cells.
3. Physical Formats & Delivery Matrices
Synthesized predominantly as high-purity lyophilized powder cakes, with secondary pre-metered pen cartridges and solution atomizers cataloged across vendors.
4. Reconstitution & Analytical Handling
Recommended reconstitution with Bacteriostatic 0.9% Benzyl Alcohol USP or Sterile Purified Water. Lyophilized cake stored at -20°C desiccated (stable up to 24 months). Solution stable at 2°C to 8°C refrigerated (stable 21 days).
Signaling Pathways & Laboratory Handling Protocols
Documented Receptor Pathways & In Vitro Signaling
Direct phosphorylation and activation of AMPK signaling cascades in skeletal muscle cells.
Stress-responsive nuclear translocation binding to chromatin to modulate adaptive gene loci.
Enhancement of cellular glucose uptake independent of insulin receptor substrate pathways.
Reduction of inflammatory cytokine secretion in explanted tissue models.
Evaluated in preclinical murine models for AMPK activation cascades, cellular glucose transport kinetics, and mitochondrial metabolic homeostasis.
Handling Parameters
Peptide Dilution & Reconstitution Calculator
Compute stock concentrations, micro-pipetting draw volumes, and U-100 syringe units with zero procedural guesswork.
Slowly introduce bacteriostatic diluent against the internal glass vial wall. Swirl gently in a circular horizontal rotation. Never shake or vortex vigorously to prevent mechanical shearing of delicate peptide bonds. Store reconstituted stock at 2°C–8°C.
Partner & Vendor Catalogues for MOTS-c
Independent partner directory providing research-grade lyophilized vials, cartridges, atomizers, and reconstitution solvents.
Category hub featuring research-grade lyophilized vials, pens, and blends.
Full catalogue category hub with multiple mg vial sizes and blends.
Dedicated category hub listing research vials and cartridges.
UK-stocked research reagent catalogue hub featuring batch-verified peptide lots.
Global catalogue hub including international dispatch batches.
Academic Bibliography & Preclinical Studies for MOTS-c
Primary academic indexing sourced from PubMed and peer-reviewed biotechnology journals documenting molecular mechanisms and in vitro cellular response.
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces diet-induced obesity
MOTS-c is an exercise-induced mitochondrial-encoded regulator of physical capacity and performance
Frequently Asked Chemical & Analytical Questions
Authoritative scientific clarifications regarding MOTS-c classification, molecular pathways, and laboratory protocols.
MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c (16-mer)) is an analytically characterized peptide compound with empirical molecular formula C101H152N28O22S2 and molecular weight 2174.6 g/mol. It is indexed under CAS Registry Number 1627580-64-6 and categorized in research literature under Cellular Longevity & Mitochondrial Axis.