Selank
Tuftsin Analog Heptapeptide (TP-7)
Selank is a synthetic regulatory heptapeptide derived from the immunomodulatory tetrapeptide tuftsin with a C-terminal Pro-Gly-Pro sequence extension. Investigated in neurochemical models for allosteric GABA-A receptor modulation, enkephalinase inhibition, and brain-derived neurotrophic factor (BDNF) mRNA expression.
Indexed for laboratory in vitro receptor binding assays and cellular synthesis research. Commercial materials are procured as non-clinical reagents under verified laboratory standards.
Chemical Structure & Metrics
Structured Chemical & Preclinical Profile
1. Chemical Identity & Sequence Architecture
Selank (Tuftsin Analog Heptapeptide (TP-7)) is an analytically characterized peptide with empirical formula C33H57N11O9 (MW 751.89 g/mol). CAS Registry: 129954-34-3.
2. Primary Preclinical Signaling Axis
Investigated in preclinical assays for cellular signaling: Allosteric positive modulation of GABA-A receptor signaling without benzodiazepine sedative liabilities.
3. Physical Formats & Delivery Matrices
Synthesized predominantly as high-purity lyophilized powder cakes, with secondary pre-metered pen cartridges and solution atomizers cataloged across vendors.
4. Reconstitution & Analytical Handling
Recommended reconstitution with Bacteriostatic Water or Sterile Isotonic Saline. Lyophilized cake stored at -20°C desiccated (stable up to 24 months). Solution stable at 2°C to 8°C refrigerated; protect from light (stable 21 days).
Signaling Pathways & Laboratory Handling Protocols
Documented Receptor Pathways & In Vitro Signaling
Allosteric positive modulation of GABA-A receptor signaling without benzodiazepine sedative liabilities.
Upregulation of BDNF and TrkB receptor mRNA transcription in the hippocampus and frontal cortex.
Inhibition of enkephalinase enzymes, attenuating degradation of endogenous leu- and met-enkephalins.
Modulation of serotonin (5-HT) and dopamine turnover rates under acute experimental conditions.
Evaluated in Eastern European clinical literature and preclinical rodent behavioral models for GABA-A receptor modulation, exploratory behavioral endpoints, and neuronal cell survival under acute stressors.
Handling Parameters
Peptide Dilution & Reconstitution Calculator
Compute stock concentrations, micro-pipetting draw volumes, and U-100 syringe units with zero procedural guesswork.
Slowly introduce bacteriostatic diluent against the internal glass vial wall. Swirl gently in a circular horizontal rotation. Never shake or vortex vigorously to prevent mechanical shearing of delicate peptide bonds. Store reconstituted stock at 2°C–8°C.
Partner & Vendor Catalogues for Selank
Independent partner directory providing research-grade lyophilized vials, cartridges, atomizers, and reconstitution solvents.
Category hub featuring research-grade lyophilized vials, pens, and blends.
Full catalogue category hub with multiple mg vial sizes and blends.
Dedicated category hub listing research vials and cartridges.
UK-stocked research reagent catalogue hub featuring batch-verified peptide lots.
Global catalogue hub including international dispatch batches.
Academic Bibliography & Preclinical Studies for Selank
Primary academic indexing sourced from PubMed and peer-reviewed biotechnology journals documenting molecular mechanisms and in vitro cellular response.
The effect of selank on the level of cytokines in blood of patients with generalized anxiety disorder
Selank regulates the expression of genes involved in neurotransmission in rat brain cells
Frequently Asked Chemical & Analytical Questions
Authoritative scientific clarifications regarding Selank classification, molecular pathways, and laboratory protocols.
Selank (Tuftsin Analog Heptapeptide (TP-7)) is an analytically characterized peptide compound with empirical molecular formula C33H57N11O9 and molecular weight 751.89 g/mol. It is indexed under CAS Registry Number 129954-34-3 and categorized in research literature under Neuropeptides & CNS Signaling.