Semax
Met-Glu-His-Phe-Pro-Gly-Pro Heptapeptide (ACTH 4-10 Pro-Gly-Pro)
Semax is a synthetic heptapeptide structurally related to the 4-10 fragment of adrenocorticotropic hormone (ACTH), stabilized by a C-terminal Pro-Gly-Pro tripeptide. It lacks hormonal endocrine activity while displaying neurotrophic and neuroprotective properties in cerebral ischemia assays.
Indexed for laboratory in vitro receptor binding assays and cellular synthesis research. Commercial materials are procured as non-clinical reagents under verified laboratory standards.
Chemical Structure & Metrics
Structured Chemical & Preclinical Profile
1. Chemical Identity & Sequence Architecture
Semax (Met-Glu-His-Phe-Pro-Gly-Pro Heptapeptide (ACTH 4-10 Pro-Gly-Pro)) is an analytically characterized peptide with empirical formula C37H51N9O10S (MW 813.93 g/mol). CAS Registry: 80714-61-0.
2. Primary Preclinical Signaling Axis
Investigated in preclinical assays for cellular signaling: Rapid induction of Brain-Derived Neurotrophic Factor (BDNF) mRNA and protein synthesis in hippocampal tissue.
3. Physical Formats & Delivery Matrices
Synthesized predominantly as high-purity lyophilized powder cakes, with secondary pre-metered pen cartridges and solution atomizers cataloged across vendors.
4. Reconstitution & Analytical Handling
Recommended reconstitution with Purified Saline USP (0.9% NaCl) or Bacteriostatic Water. Lyophilized cake stored at -20°C in dark storage. Solution stable at 2°C to 8°C refrigerated; do not freeze solution.
Signaling Pathways & Laboratory Handling Protocols
Documented Receptor Pathways & In Vitro Signaling
Rapid induction of Brain-Derived Neurotrophic Factor (BDNF) mRNA and protein synthesis in hippocampal tissue.
Activation of TrkB receptor autophosphorylation and downstream PI3K/Akt neuroprotective cascades.
Regulation of monoamine turnover, elevating extracellular dopamine and serotonin in striatal tissue slices.
Stabilization of cerebral microcirculation during hypoperfusion without systemic blood pressure alteration.
Demonstrated mucosal permeability in nasal spray formulations, enabling direct olfactory bulb transport across the blood-brain barrier in rodent neuro-pharmacology assays.
Handling Parameters
Peptide Dilution & Reconstitution Calculator
Compute stock concentrations, micro-pipetting draw volumes, and U-100 syringe units with zero procedural guesswork.
Slowly introduce bacteriostatic diluent against the internal glass vial wall. Swirl gently in a circular horizontal rotation. Never shake or vortex vigorously to prevent mechanical shearing of delicate peptide bonds. Store reconstituted stock at 2°C–8°C.
Partner & Vendor Catalogues for Semax
Independent partner directory providing research-grade lyophilized vials, cartridges, atomizers, and reconstitution solvents.
Category hub featuring research-grade lyophilized vials, pens, and blends.
Full catalogue category hub with multiple mg vial sizes and blends.
Dedicated category hub listing research vials and cartridges.
UK-stocked research reagent catalogue hub featuring batch-verified peptide lots.
Global catalogue hub including international dispatch batches.
Academic Bibliography & Preclinical Studies for Semax
Primary academic indexing sourced from PubMed and peer-reviewed biotechnology journals documenting molecular mechanisms and in vitro cellular response.
Semax, an ACTH(4-10) analogue with nootropic properties, stimulates BDNF synthesis in the rat brain
Heptapeptide Semax and its neuroprotective effects in models of acute cerebral hypoperfusion
The peptide Semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia
Frequently Asked Chemical & Analytical Questions
Authoritative scientific clarifications regarding Semax classification, molecular pathways, and laboratory protocols.
Semax (Met-Glu-His-Phe-Pro-Gly-Pro Heptapeptide (ACTH 4-10 Pro-Gly-Pro)) is an analytically characterized peptide compound with empirical molecular formula C37H51N9O10S and molecular weight 813.93 g/mol. It is indexed under CAS Registry Number 80714-61-0 and categorized in research literature under Neuropeptides & CNS Signaling.